Searchable abstracts of presentations at key conferences in endocrinology

ea0035p40 | Adrenal cortex | ECE2014

21-hydroxylase autoantibody positivity is influenced by HLA genotype in South African patients with Addison's disease

Ross Ian , Babu Sunanda , Yu Liping , Armstrong Taylor , Zhang Li , Schatz Desmond , Pugliese Alberto , Eisenbarth George , Baker Peter

Background: Data examining HLA associations in Addison’s disease (AD) from South Africa (SA) are limited. We wished to determine the HLA in South African AD patients either positive or negative for 21 hydroxylase autoantibodies (21 OH-AA) and matched healthy controls, hypothesising that certain HLA alleles could predominate, but there may be differences from Western countries.Methods: SA patients (n=73) were enrolled as part of a nationwide...